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Indifference: This may come as a result of age and a subsequent loss of interest in sex, be the result of medications or stem from problems in a couple's relationship. Methods and results 285 patients with CAD divided into three age-matched groups: group 1 (G1, n = 95), ACS and one-vessel disease (1-VD); group 2 (G2, n = 95), ACS and 2,3-VD; group 3 (G3, n = 95), chronic CS. Control group (C, n = 95) was composed of patients with suspected CAD who were found to have entirely normal coronary arteries by angiography. Gensini's score used to assess extent of CAD. ED as any value < 26 according to the International Index of Erectile Function (IIEF). ED prevalence was lower in G1 vs. G3 (22 vs. 65%, P < .0001) as a result of less atherosclerotic burden as expressed by Gensini's score [2 (0-6) vs. 40 (19-68), P = 0.0001]. Controls had ED rate values similar to G1 (24%). Group 2 ED rate, IIEF, and Gensini's scores were significantly different from G1 [55%, P < 0.0001; 24 (17-29), P = 0.0001; 21 (12.5-32), P < 0.0001] and similar to G3 suggesting that despite similar clinical presentation, ED in ACS differs according to the extent of CAD. No significant difference between groups was found in the number and type of conventional risk factors. Treatment with beta-blockers was more frequent in G3 vs. G1 and G2. In G3 patients who had ED, onset of sexual dysfunction occurred before CAD onset in 93%, with a mean time interval of 24 [12-36] months. In logistic regression analysis, age (OR=1.1; 95% confidence interval (CI), 1.05-1.16; P = < 0.0001), multi-vessel vs. single-vessel (OR=2.53; 95% CI, 1.43-4.51; P = 0.0002), and CCS vs. ACS (OR=2.32; 95% CI, 1.22-4.41; P = 0.01) were independent predictors of ED. The new cream consists of nanoparticles that can carry drugs or other substances, such as nitric oxide, and deliver them in a controlled and sustained manner, according to the researchers, who are from Albert Einstein College of Medicine at Yeshiva University in New York City. Nitric oxide is the signaling molecule that dilates blood vessels responsible for creating an erection. Semirigid or malleable rod implants Simple surgery more